Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p173 | (1) | WCRB2014

Fibrotic remodeling and duct obstruction are major patho-physiological mechanisms in bacterial epididymitis in mice

Michel Vera , Bhushan Sudhanshu , Middendorff Ralf , Loveland Kate L , de Kretser David D , Hedger Mark P , Meinhardt Andreas

Introduction: Bacterial epididymitis is a common disorder in urological outpatient clinics and usually results from ascending infections originating in the urinary tract often involving uropathogenic E. coli (UPEC) as causative pathogen. In 40% of patients with acute epididymitis, impaired semen parameters persist even after antibiotic treatment. Members of the TGFβ cytokine superfamily, such as activin A, have recently been identified in the epididymis and are c...